Complement receptor 1 genetic polymorphism contributes to sporadic Alzheimer's disease susceptibility in Caucasians: a meta-analysis.

ABSTRACT: Complement receptor 1 (CR1) plays an important role in the development of sporadic Alzheimer's disease (SAD) in Caucasians. However, the influence of CR1 (rs6656401A/G and rs3818361T/C) genetic polymorphisms on the risk of SAD remains controversial. A meta-analysis of 18 case-control studies was performed to derive a more precise association of CR1 (rs6656401A/G or rs3818361T/C) genetic polymorphism with the risk of SAD in Caucasians. A statistical difference was found in the dominant model (odds ratio (OR): 1.23, 95% confidence interval (CI): 1.16-1.30, P=0.00), recessive model (OR: 1.28, 95% CI: 1.05-1.56, P=0.02), homozygote comparison (OR: 1.36, 95% CI: 1.12-1.66, P=0.002) or heterozygote comparison (AG versus GG) (OR: 1.21, 95% CI: 1.15-1.29, P=0.00) of CR1 rs6656401A/G. For CR1 rs381

SUBMITTER: Yuan H 

PROVIDER: S-EPMC7268259 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature