DNA methylation loci in placenta associated with birthweight and expression of genes relevant for early development and adult diseases.
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ABSTRACT:
SUBMITTER: Tekola-Ayele F
PROVIDER: S-EPMC7268466 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Publications
DNA methylation loci in placenta associated with birthweight and expression of genes relevant for early development and adult diseases.
Tekola-Ayele Fasil F Zeng Xuehuo X Ouidir Marion M Workalemahu Tsegaselassie T Zhang Cuilin C Delahaye Fabien F Wapner Ronald R
Clinical epigenetics 20200603 1
<h4>Background</h4>Birthweight marks an important milestone of health across the lifespan, including cardiometabolic disease risk in later life. The placenta, a transient organ at the maternal-fetal interface, regulates fetal growth. Identifying genetic loci where DNA methylation in placenta is associated with birthweight can unravel genomic pathways that are dysregulated in aberrant fetal growth and cardiometabolic diseases in later life.<h4>Results</h4>We performed placental epigenome-wide ass ...[more]
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