Dataset Information

The minimal informative monitoring interval of N-terminal pro-B-type natriuretic peptide in patients with stable heart failure.

ABSTRACT:

Background

N-terminal pro-B-type natriuretic peptide (NT-proBNP) is a potential biomarker for monitoring the status of heart failure. However, the optimal monitoring interval of NT-proBNP is unknown. This study sought to investigate the minimal informative monitoring interval of NT-proBNP in patients with stable chronic heart failure.

Methods

This retrospective cohort study included patients who were admitted due to heart failure and subsequently followed with serial NT-proBNP measurements in a tertiary hospital. We analyzed NT-proBNP measured between six months after discharge and the earliest timepoint of: an alteration of medication regimen, readmission due to worsening of heart failure, or all-cause death. To distinguish progression of the disease from biological variability and measurement error, the signal-to-noise ratio method was applied with a random-effects model.

Results

In the 368 patients included, NT-proBNP was measured for a median 6 times. In the random-effects model, signal (progression of disease) exceeded noise (biological variability and measurement error) at 7.9?months (95% confidence interval [CI]: 5.1-9.6), while noise corresponded to a 61% increase from baseline. In stratified analysis using the AHEAD risk score, the minimal informative monitoring interval shortened as the risk score increased (0-1 point: 12.2?months [95%CI: 10.3-14.4]; 2-3 points: 8.0?months [95%CI: 6.8-9.7]; 4-5 points: 3.3?months [95%CI: 3.0-3.8]).

Conclusions

In patients with stable chronic heart failure, the minimal informative monitoring interval of NT-proBNP measurement was 7.9?months in the current population, which varied with underlying risks. The optimal monitoring interval could be lengthened for patients at lower risks.

SUBMITTER: Dai Z

PROVIDER: S-EPMC7268659 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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Publications

The minimal informative monitoring interval of N-terminal pro-B-type natriuretic peptide in patients with stable heart failure.

Dai Zhehao Z Asano Taku T Takahashi Osamu O Komiyama Nobuyuki N Ohde Sachiko S

BMC cardiovascular disorders 20200601 1

<h4>Background</h4>N-terminal pro-B-type natriuretic peptide (NT-proBNP) is a potential biomarker for monitoring the status of heart failure. However, the optimal monitoring interval of NT-proBNP is unknown. This study sought to investigate the minimal informative monitoring interval of NT-proBNP in patients with stable chronic heart failure.<h4>Methods</h4>This retrospective cohort study included patients who were admitted due to heart failure and subsequently followed with serial NT-proBNP mea ...[more]

PMID: 32487160

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Dataset Information

The minimal informative monitoring interval of N-terminal pro-B-type natriuretic peptide in patients with stable heart failure.

Background

Methods

Results

Conclusions

Publications

The minimal informative monitoring interval of N-terminal pro-B-type natriuretic peptide in patients with stable heart failure.

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