Ontology highlight
ABSTRACT:
SUBMITTER: Wang J
PROVIDER: S-EPMC7269845 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Wang Junmei J Hasan Farah F Frey Amanda C AC Li Haiyan S HS Park Jungsun J Pan Ke K Haymaker Cara C Bernatchez Chantale C Lee Dean A DA Watowich Stephanie S SS Yee Cassian C
Cancer immunology research 20200325 6
Clinical response rates after adoptive cell therapy (ACT) are highly correlated with <i>in vivo</i> persistence of the infused T cells. However, antigen-specific T cells found in tumor sites are often well-differentiated effector cells with limited persistence. Central memory CD8<sup>+</sup> T cells, capable of self-renewal, represent desirable ACT products. We report here that exposure to a histone deacetylase inhibitor (HDACi) and IL21 could reprogram differentiated human CD8<sup>+</sup> T cel ...[more]