Differential expression profiles of circRNAs in human prostate cancer based on chip and bioinformatic analysis.
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ABSTRACT: Background
Increasing evidence suggests that circRNAs are involved in the pathogenesis of multiple kinds of cancer. Nevertheless, the differential expression of circRNAs in prostate cancer (PCA) is rarely reported.Material/method
In our present analyses, circRNAs expression profiles were identified in PCA, based on 5 pairs of PCA and matched non-PCA tissues using circRNA chips.Results
A number of 749 differential circRNAs were expressed between PCA tumor and paracancerous tissues (Fold Change, FC ? 2.0 and P < 0.05): 261 were upregulated, whereas 487 were downregulated in PCA tissues. Gene ontology and KEGG pathway analyses indicated that many of the circRNAs are related to carcinogenesis. Circ_0033074 and circ_0016064 both showed changes of maximum magnitude among differentially expressed circRNAs.Conclusions
Our study detected a relative comprehensive differential map of circRNAs in PCA, which may become novel biomarkers for diagnosis, treatment and follow-up in the future.
SUBMITTER: Ge S
PROVIDER: S-EPMC7270690 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
Differential expression profiles of circRNAs in human prostate cancer based on chip and bioinformatic analysis.
Ge Shengyang S Sun Chuanyu C Hu Qingfeng Q Guo Yijun Y Xia Guowei G Mi Yuanyuan Y Zhu Lijie L
International journal of clinical and experimental pathology 20200501 5
<h4>Background</h4>Increasing evidence suggests that circRNAs are involved in the pathogenesis of multiple kinds of cancer. Nevertheless, the differential expression of circRNAs in prostate cancer (PCA) is rarely reported.<h4>Material/method</h4>In our present analyses, circRNAs expression profiles were identified in PCA, based on 5 pairs of PCA and matched non-PCA tissues using circRNA chips.<h4>Results</h4>A number of 749 differential circRNAs were expressed between PCA tumor and paracancerous ...[more]
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