Unknown

Dataset Information

0

Pterostilbene complexed with cyclodextrin exerts antimicrobial and anti-inflammatory effects.


ABSTRACT: Resveratrol (RES) is a natural polyphenol with potential as an adjunctive therapeutic modality for periodontitis. However, its inferior pharmacokinetics and toxicity concerns about its commonly used solvent dimethyl sulfoxide (DMSO) hinder translation to clinical applicability. Our study aimed to investigate the comparative antimicrobial properties of RES and its analogues (pterostilbene [PTS], oxyresveratrol [OXY] and piceatannol [PIC]), utilizing 2-hydroxypropyl-?-cyclodextrin (HP?CD) as a solubiliser, which has a well-documented safety profile and FDA approval. These properties were investigated against Fusobacterium nucleatum, a key periodontal pathogen. PTS demonstrated the most potent antibacterial effects in HP?CD, with MIC?>?60-fold lower than that of RES, OXY and PIC. In addition, PTS inhibited F. nucleatum biofilm formation. PTS exerted antimicrobial effects by eliciting leakage of cellular contents, leading to loss of bacterial cell viability. PTS also conferred immunomodulatory effects on F. nucleatum-challenged macrophages via upregulation of antioxidant pathways and inhibition of NF-?B activation. Given the superior antimicrobial potency of PTS against F. nucleatum compared to RES and other analogues, and coupled with its immunomodulatory properties, PTS complexed with HP?CD holds promise as a candidate nutraceutical for the adjunctive treatment of periodontitis.

SUBMITTER: Lim YRI 

PROVIDER: S-EPMC7271226 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

altmetric image

Publications

Pterostilbene complexed with cyclodextrin exerts antimicrobial and anti-inflammatory effects.

Lim Yi Rong Ivan YRI   Preshaw Philip M PM   Lim Lum Peng LP   Ong Marianne Meng Ann MMA   Lin Hai-Shu HS   Tan Kai Soo KS  

Scientific reports 20200603 1


Resveratrol (RES) is a natural polyphenol with potential as an adjunctive therapeutic modality for periodontitis. However, its inferior pharmacokinetics and toxicity concerns about its commonly used solvent dimethyl sulfoxide (DMSO) hinder translation to clinical applicability. Our study aimed to investigate the comparative antimicrobial properties of RES and its analogues (pterostilbene [PTS], oxyresveratrol [OXY] and piceatannol [PIC]), utilizing 2-hydroxypropyl-β-cyclodextrin (HPβCD) as a sol  ...[more]

Similar Datasets

| S-EPMC4653649 | biostudies-literature
| S-EPMC9445084 | biostudies-literature
| S-EPMC6174543 | biostudies-literature
| S-EPMC10796079 | biostudies-literature
| S-EPMC9096387 | biostudies-literature
| S-EPMC5878047 | biostudies-literature
| S-EPMC7901009 | biostudies-literature
| S-EPMC2643824 | biostudies-literature
| S-EPMC11367751 | biostudies-literature
| S-EPMC7795859 | biostudies-literature