Ontology highlight
ABSTRACT:
SUBMITTER: Bera S
PROVIDER: S-EPMC7271323 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Bera Sujoy S Camblor-Perujo Santiago S Calleja Barca Elena E Negrete-Hurtado Albert A Racho Julia J De Bruyckere Elodie E Wittich Christoph C Ellrich Nina N Martins Soraia S Adjaye James J Kononenko Natalia L NL
EMBO reports 20200423 6
Cleavage of amyloid precursor protein (APP) by BACE-1 (β-site APP cleaving enzyme 1) is the rate-limiting step in amyloid-β (Aβ) production and a neuropathological hallmark of Alzheimer's disease (AD). Despite decades of research, mechanisms of amyloidogenic APP processing remain highly controversial. Here, we show that in neurons, APP processing and Aβ production are controlled by the protein complex-2 (AP-2), an endocytic adaptor known to be required for APP endocytosis. Now, we find that AP-2 ...[more]