The role of testosterone in chronic kidney disease and kidney function in men and women: a bi-directional Mendelian randomization study in the UK Biobank.
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ABSTRACT:
SUBMITTER: Zhao JV
PROVIDER: S-EPMC7271464 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
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The role of testosterone in chronic kidney disease and kidney function in men and women: a bi-directional Mendelian randomization study in the UK Biobank.
Zhao Jie V JV Schooling C Mary CM
BMC medicine 20200604 1
<h4>Background</h4>Chronic kidney disease (CKD) has an apparent sex disparity, with a more rapid progress in men than in women. Whether the well-established sex-specific evolutionary biology trade-off between reproduction and longevity might inform CKD has not previously been considered. Relevant evidence from randomized controlled trials (RCTs) is not available.<h4>Methods</h4>We used a bi-directional Mendelian randomization study to obtain unconfounded estimates using the UK Biobank. Single nu ...[more]
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