Ontology highlight
ABSTRACT:
SUBMITTER: Wilson HE
PROVIDER: S-EPMC7272425 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Wilson Hannah E HE Stanton David A DA Montgomery Cortney C Infante Aniello M AM Taylor Matthew M Hazard-Jenkins Hannah H Pugacheva Elena N EN Pistilli Emidio E EE
NPJ breast cancer 20200604
Increased susceptibility to fatigue is a negative predictor of survival commonly experienced by women with breast cancer (BC). Here, we sought to identify molecular changes induced in human skeletal muscle by BC regardless of treatment history or tumor molecular subtype using RNA-sequencing (RNA-seq) and proteomic analyses. Mitochondrial dysfunction was apparent across all molecular subtypes, with the greatest degree of transcriptomic changes occurring in women with HER2/neu-overexpressing tumor ...[more]