Ontology highlight
ABSTRACT:
SUBMITTER: Mick E
PROVIDER: S-EPMC7273244 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Mick Eran E Kamm Jack J Pisco Angela Oliveira AO Ratnasiri Kalani K Babik Jennifer M JM Calfee Carolyn S CS Castañeda Gloria G DeRisi Joseph L JL Detweiler Angela M AM Hao Samantha S Kangelaris Kirsten N KN Kumar G Renuka GR Li Lucy M LM Mann Sabrina A SA Neff Norma N Prasad Priya A PA Serpa Paula Hayakawa PH Shah Sachin J SJ Spottiswoode Natasha N Tan Michelle M Christenson Stephanie A SA Kistler Amy A Langelier Charles C
medRxiv : the preprint server for health sciences 20200519
We studied the host transcriptional response to SARS-CoV-2 by performing metagenomic sequencing of upper airway samples in 238 patients with COVID-19, other viral or non-viral acute respiratory illnesses (ARIs). Compared to other viral ARIs, COVID-19 was characterized by a diminished innate immune response, with reduced expression of genes involved in toll-like receptor and interleukin signaling, chemokine binding, neutrophil degranulation and interactions with lymphoid cells. Patients with COVI ...[more]