Polymorphic Inversions Underlie the Shared Genetic Susceptibility of Obesity-Related Diseases.
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ABSTRACT:
SUBMITTER: Gonzalez JR
PROVIDER: S-EPMC7273535 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
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Polymorphic Inversions Underlie the Shared Genetic Susceptibility of Obesity-Related Diseases.
González Juan R JR Ruiz-Arenas Carlos C Cáceres Alejandro A Morán Ignasi I López-Sánchez Marcos M Alonso Lorena L Tolosana Ignacio I Guindo-Martínez Marta M Mercader Josep M JM Esko Tonu T Torrents David D González Josefa J Pérez-Jurado Luis A LA
American journal of human genetics 20200528 6
The burden of several common diseases including obesity, diabetes, hypertension, asthma, and depression is increasing in most world populations. However, the mechanisms underlying the numerous epidemiological and genetic correlations among these disorders remain largely unknown. We investigated whether common polymorphic inversions underlie the shared genetic influence of these disorders. We performed an inversion association analysis including 21 inversions and 25 obesity-related traits on a to ...[more]
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