EndoPredict® in early hormone receptor-positive, HER2-negative breast cancer.

ABSTRACT: PURPOSE:Evaluating consecutive early breast cancer patients, we analyzed both the impact of EndoPredict® on clinical decisions as well as clinico-pathological factors influencing the decision to perform this gene expression test. METHODS:Hormone receptor (HR)-positive and human epidermal growth factor receptor 2 (HER2)-negative early breast cancer patients treated between 2011 and 2016 were included in this study to investigate the role of EndoPredict® (EPclin) in the treatment of early breast cancer. A main study aim was to analyze the changes in therapy recommendations with and without EPclin. In addition, the impact of clinico-pathological parameters for the decision to perform EPclin was examined by Pearson's chi-squared test (?2-test) and Fisher's exact test as well as univariate and multivariate logistic regressions. RESULTS:In a cohort of 869 consecutive early HR-positive, HER-negative breast cancer patients, EPclin was utilized in 156 (18.0%) patients. EPclin led to changes in therapy recommendations in 33.3% (n?=?52), with both therapy escalation in 19.2% (n?=?30) and de-escalation in 14.1% (n?=?22). The clinico-pathological factors influencing the use of EPclin were age (P?

SUBMITTER: Almstedt K 

PROVIDER: S-EPMC7275019 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature