Ontology highlight
ABSTRACT:
SUBMITTER: Meng K
PROVIDER: S-EPMC7275070 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Meng Kun K Zhuang Xiaohui X Peng Ting T Hu Shufan S Yang Jin J Wang Zhen Z Fu Jiaqi J Xue Juan J Pan Xing X Lv Jun J Liu Xiaoyun X Shao Feng F Li Shan S
Communications biology 20200605 1
Salmonella enterica serovar Typhimurium, an intracellular Gram-negative bacterial pathogen, employs two type III secretion systems to deliver virulence effector proteins to host cells. One such effector, SseK3, is a Golgi-targeting arginine GlcNAc transferase. Here, we show that SseK3 colocalizes with cis-Golgi via lipid binding. Arg-GlcNAc-omics profiling reveals that SseK3 modifies Rab1 and some phylogenetically related Rab GTPases. These modifications are dependent on C-termini of Rabs but in ...[more]