Ontology highlight
ABSTRACT:
SUBMITTER: Gupta R
PROVIDER: S-EPMC7275752 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Gupta Romi R Malvi Parmanand P Parajuli Keshab Raj KR Janostiak Radoslav R Bugide Suresh S Cai Guoping G Zhu Lihua Julie LJ Green Michael R MR Wajapeyee Narendra N
Proceedings of the National Academy of Sciences of the United States of America 20200519 22
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with a dismal prognosis. Currently, there is no effective therapy for PDAC, and a detailed molecular and functional evaluation of PDACs is needed to identify and develop better therapeutic strategies. Here we show that the transcription factor Krüppel-like factor 7 (KLF7) is overexpressed in PDACs, and that inhibition of KLF7 blocks PDAC tumor growth and metastasis in cell culture and in mice. KLF7 expression in PDACs can be up-regu ...[more]