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Mersaquinone, A New Tetracene Derivative from the Marine-Derived Streptomyces sp. EG1 Exhibiting Activity against Methicillin-Resistant Staphylococcus aureus (MRSA).

ABSTRACT: New antibiotics are desperately needed to overcome the societal challenges being encountered with methicillin-resistant Staphylococcus aureus (MRSA). In this study, a new tetracene derivative, named Mersaquinone (1), and the known Tetracenomycin D (2), Resistoflavin (3) and Resistomycin (4) have been isolated from the organic extract of the marine Streptomyces sp. EG1. The strain was isolated from a sediment sample collected from the North Coast of the Mediterranean Sea of Egypt. The chemical structure of Mersaquinone (1) was assigned based upon data from a diversity of spectroscopic techniques including HRESIMS, IR, 1D and 2D NMR measurements. Mersaquinone (1) showed antibacterial activity against methicillin-resistant Staphylococcus aureus with a minimum inhibitory concentration of 3.36 ?g/mL.

SUBMITTER: Kim MC 

PROVIDER: S-EPMC7277363 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature

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Mersaquinone, A New Tetracene Derivative from the Marine-Derived <i>Streptomyces</i> sp. EG1 Exhibiting Activity against Methicillin-Resistant <i>Staphylococcus aureus</i> (MRSA).

Kim Min Cheol MC   Cullum Reiko R   Hebishy Ali M S AMS   Mohamed Hala A HA   Faraag Ahmed H I AHI   Salah Nehad M NM   Abdelfattah Mohamed S MS   Fenical William W  

Antibiotics (Basel, Switzerland) 20200514 5

New antibiotics are desperately needed to overcome the societal challenges being encountered with methicillin-resistant <i>Staphylococcus aureus</i> (MRSA). In this study, a new tetracene derivative, named Mersaquinone (<b>1</b>), and the known Tetracenomycin D (<b>2</b>), Resistoflavin (<b>3</b>) and Resistomycin (<b>4</b>) have been isolated from the organic extract of the marine <i>Streptomyces</i> sp. EG1. The strain was isolated from a sediment sample collected from the North Coast of the M  ...[more]

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