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A new anthracene derivative from marine Streptomyces sp. W007 exhibiting highly and selectively cytotoxic activities.


ABSTRACT: A new anthracene derivative, 3-hydroxy-1-keto-3-methyl-8-methoxy-1,2,3, 4-tetrahydro-benz[?]anthracene, was isolated from the marine strain Streptomyces sp. W007, and its structure was established by spectroscopic analysis including mass spectra, 1D- and 2D-NMR ((1)H-(1)H COSY, HMBC, HSQC and NOESY) experiments. 3-hydroxy-1-keto-3-methyl-8-methoxy-1,2,3,4-tetrahydro-benz[?]anthracene showed cytotoxicity against human lung adenocarcinoma cell line A549.

SUBMITTER: Zhang H 

PROVIDER: S-EPMC3225931 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature

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A new anthracene derivative from marine Streptomyces sp. W007 exhibiting highly and selectively cytotoxic activities.

Zhang Hongyu H   Wang Hongpeng H   Cui Hongli H   Li Zonggang Z   Xie Zeping Z   Pu Yang Y   Li Fuchao F   Qin Song S  

Marine drugs 20110909 9


A new anthracene derivative, 3-hydroxy-1-keto-3-methyl-8-methoxy-1,2,3, 4-tetrahydro-benz[α]anthracene, was isolated from the marine strain Streptomyces sp. W007, and its structure was established by spectroscopic analysis including mass spectra, 1D- and 2D-NMR ((1)H-(1)H COSY, HMBC, HSQC and NOESY) experiments. 3-hydroxy-1-keto-3-methyl-8-methoxy-1,2,3,4-tetrahydro-benz[α]anthracene showed cytotoxicity against human lung adenocarcinoma cell line A549. ...[more]

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