A SNP, Gene, and Polygenic Risk Score Approach of Oxytocin-Vasopressin Genes in Adolescents' Loneliness.
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ABSTRACT:
SUBMITTER: Verhagen M
PROVIDER: S-EPMC7277497 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Publications
A SNP, Gene, and Polygenic Risk Score Approach of Oxytocin-Vasopressin Genes in Adolescents' Loneliness.
Verhagen Maaike M Verweij Karin J H KJH Lodder Gerine M A GMA Goossens Luc L Verschueren Karine K Van Leeuwen Karla K Van den Noortgate Wim W Claes Stephan S Bijttebier Patricia P Van Assche Evelien E Vink Jaqueline M JM
Journal of research on adolescence : the official journal of the Society for Research on Adolescence 20190129
Not much is known regarding underlying biological pathways to adolescents' loneliness. Insight in underlying molecular mechanisms could inform intervention efforts aimed at reducing loneliness. Using latent growth curve modeling, baseline levels and development of loneliness were studied in two longitudinal adolescent samples. Genes (OXTR, OXT, AVPR1A, AVPR1B) were examined using SNP-based, gene-based, and polygenic risk score (PRS) approaches. In both samples, SNP- and gene-based tests showed i ...[more]
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