Unequal twins: Unraveling the reaction mechanism of dimeric histidine kinases.
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ABSTRACT:
SUBMITTER: Gartner W
PROVIDER: S-EPMC7278345 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Publications
Unequal twins: Unraveling the reaction mechanism of dimeric histidine kinases.
The Journal of biological chemistry 20200601 23
Histidine kinases (HKs), together with their partner proteins, the response regulators (RRs), form the ubiquitous two-component systems that are global players in control and adjustment of microbial lifestyle. Although their basic function (<i>i.e.</i> the transfer of a phosphate group from the HK to its RR partner) is simple to articulate, deciphering the molecular details of this process has proven anything but simple, especially when quantitative aspects come into play. Bouillet <i>et al.</i> ...[more]
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