Ontology highlight
ABSTRACT:
SUBMITTER: Liu WC
PROVIDER: S-EPMC7278944 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Liu Wen-Chih WC Shyu Jia-Fwu JF Lim Paik Seong PS Fang Te-Chao TC Lu Chien-Lin CL Zheng Cai-Mei CM Hou Yi-Chou YC Wu Chia-Chao CC Lin Yuh-Feng YF Lu Kuo-Cheng KC
International journal of molecular sciences 20200515 10
Indoxyl sulfate (IS) is a chronic kidney disease (CKD)-specific renal osteodystrophy metabolite that affects the nuclear factor of activated T-cells, cytoplasmic 1 (NFATc1), a transcription factor promoting osteoclastogenesis. However, the mechanisms underlying the regulation of NFATc1 by IS remain unknown. It is intriguing that the Aryl hydrocarbon receptor (AhR) plays a key role in osteoclastogenesis, since IS is an endogenous AhR agonist. This study investigates the relationship between IS co ...[more]