Ontology highlight
ABSTRACT:
SUBMITTER: Chiritoiu M
PROVIDER: S-EPMC7279049 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Chiritoiu Marioara M Chiritoiu Gabriela N GN Munteanu Cristian V A CVA Pastrama Florin F Ivessa N Erwin NE Petrescu Stefana M SM
International journal of molecular sciences 20200514 10
Endoplasmic reticulum (ER)-associated degradation (ERAD) is the main mechanism of targeting ER proteins for degradation to maintain homeostasis, and perturbations of ERAD lead to pathological conditions. ER-degradation enhancing α-mannosidase-like (EDEM1) was proposed to extract terminally misfolded proteins from the calnexin folding cycle and target them for degradation by ERAD. Here, using mass-spectrometry and biochemical methods, we show that EDEM1 is found in auto-regulatory complexes with ...[more]