Ontology highlight
ABSTRACT:
SUBMITTER: Fregno I
PROVIDER: S-EPMC8327951 | biostudies-literature | 2021 Aug
REPOSITORIES: biostudies-literature
Fregno Ilaria I Fasana Elisa E Soldà Tatiana T Galli Carmela C Molinari Maurizio M
The EMBO journal 20210621 15
Efficient degradation of by-products of protein biogenesis maintains cellular fitness. Strikingly, the major biosynthetic compartment in eukaryotic cells, the endoplasmic reticulum (ER), lacks degradative machineries. Misfolded proteins in the ER are translocated to the cytosol for proteasomal degradation via ER-associated degradation (ERAD). Alternatively, they are segregated in ER subdomains that are shed from the biosynthetic compartment and are delivered to endolysosomes under control of ER- ...[more]