Ontology highlight
ABSTRACT:
SUBMITTER: Cezanne A
PROVIDER: S-EPMC7279886 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Cezanne Alice A Lauer Janelle J Solomatina Anastasia A Sbalzarini Ivo F IF Zerial Marino M
eLife 20200608
Proteins can self-organize into spatial patterns via non-linear dynamic interactions on cellular membranes. Modelling and simulations have shown that small GTPases can generate patterns by coupling guanine nucleotide exchange factors (GEF) to effectors, generating a positive feedback of GTPase activation and membrane recruitment. Here, we reconstituted the patterning of the small GTPase Rab5 and its GEF/effector complex Rabex5/Rabaptin5 on supported lipid bilayers. We demonstrate a 'handover' of ...[more]