Ontology highlight
ABSTRACT:
SUBMITTER: Goering R
PROVIDER: S-EPMC7279889 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Goering Raeann R Hudish Laura I LI Guzman Bryan B BB Raj Nisha N Bassell Gary J GJ Russ Holger A HA Dominguez Daniel D Taliaferro J Matthew JM
eLife 20200608
The sorting of RNA molecules to subcellular locations facilitates the activity of spatially restricted processes. We have analyzed subcellular transcriptomes of FMRP-null mouse neuronal cells to identify transcripts that depend on FMRP for efficient transport to neurites. We found that these transcripts contain an enrichment of G-quadruplex sequences in their 3' UTRs, suggesting that FMRP recognizes them to promote RNA localization. We observed similar results in neurons derived from Fragile X S ...[more]