Ontology highlight
ABSTRACT:
SUBMITTER: Masuzawa T
PROVIDER: S-EPMC7081427 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Masuzawa Tatsuki T Oyoshi Takanori T
ACS omega 20200305 10
G-quadruplexes have important biologic functions that are regulated by G-quadruplex-binding proteins. In particular, G-quadruplex structures are folded or unfolded by their binding proteins and affect transcription and other biologic functions. Here, we investigated the effect of the RNA recognition motif (RRM) and arginine-glycine-glycine repeat (RGG) domain of nucleolin on G-quadruplex formation. Our findings indicate that Phe in the RGG domain of nucleolin is responsible for G-quadruplex bind ...[more]