Transcriptional and imaging-genetic association of cortical interneurons, brain function, and schizophrenia risk.

ABSTRACT: Inhibitory interneurons orchestrate information flow across the cortex and are implicated in psychiatric illness. Although interneuron classes have unique functional properties and spatial distributions, the influence of interneuron subtypes on brain function, cortical specialization, and illness risk remains elusive. Here, we demonstrate stereotyped negative correlation of somatostatin and parvalbumin transcripts within human and non-human primates. Cortical distributions of somatostatin and parvalbumin cell gene markers are strongly coupled to regional differences in functional MRI variability. In the general population (n = 9,713), parvalbumin-linked genes account for an enriched proportion of heritable variance in in-vivo functional MRI signal amplitude. Single-marker and polygenic cel

SUBMITTER: Anderson KM 

PROVIDER: S-EPMC7280213 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature