Human cortical transcriptome informs brain imaging
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
PROVIDER: GSE58604 | GEO | 2015/11/18
SECONDARY ACCESSION(S): PRJNA253002
REPOSITORIES: GEO
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This model is described in the article:
Mathematical analysis of the
influence of brain metabolism on the BOLD signal in Alzheimer's
disease
Felix Winter1,2, Catrin
Bludszuweit-Philipp1 and Olaf Wolkenhauer2,3
Journal of Cerebral Blood Flow &
Metabolism
Abstract:
Blood oxygen level-dependent functional magnetic resonance
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observed behaviour need to be known. The parameters of the
canonical hemodynamic response function (HRF) commonly used in
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interpretation and cannot be used to answer this question. We
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in the BOLD shape to changes in the underlying energy
metabolism. According to our findings, the classic view that
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strength and duration of the stimulus does not hold. Instead,
peak height, peak timing and full width at half maximum are
sensitive to changes in the reaction rate of several metabolic
reactions. Our systems-theoretic approach allows the use of
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fMRI analyses in AD patients.
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