Ontology highlight
ABSTRACT:
SUBMITTER: Mansouri H
PROVIDER: S-EPMC7281089 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Mansouri Hanane H Alcaraz Lindsay B LB Mollevi Caroline C Mallavialle Aude A Jacot William W Boissière-Michot Florence F Simony-Lafontaine Joelle J Laurent-Matha Valérie V Roger Pascal P Liaudet-Coopman Emmanuelle E Guiu Séverine S
Cancers 20200515 5
<h4>Background</h4>In the triple-negative breast cancer (TNBC) group, the luminal androgen receptor subtype is characterized by expression of androgen receptor (AR) and lack of estrogen receptor and cytokeratin 5/6 expression. Cathepsin D (Cath-D) is overproduced and hypersecreted by breast cancer (BC) cells and is a poor prognostic marker. We recently showed that in TNBC, Cath-D is a potential target for antibody-based therapy. This study evaluated the frequency of AR/Cath-D co-expression and i ...[more]