Ontology highlight
ABSTRACT:
SUBMITTER: Huynh JC
PROVIDER: S-EPMC7281439 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Huynh Jasmine C JC Schwab Erin E Ji Jingran J Kim Edward E Joseph Anjali A Hendifar Andrew A Cho May M Gong Jun J
Cancers 20200506 5
The treatment of advanced gastrointestinal (GI) cancers has become increasingly molecularly driven. Molecular profiling for HER2 and PD-L1 status is standard for metastatic gastroesophageal (GEJ) cancers to predict benefits from trastuzumab (HER2-targeted therapy) and pembrolizumab (anti-PD-1 therapy), while extended RAS and BRAF testing is standard in metastatic colorectal cancer to predict benefits from epidermal growth factor receptor (EGFR)-targeted therapies. Mismatch repair (MMR) or micros ...[more]