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Mantonico and Pecorello Grape Seed Extracts: Chemical Characterization and Evaluation of In Vitro Wound-Healing and Anti-Inflammatory Activities.


ABSTRACT: The winemaking process produces a huge number of pomaces that generally are used for energy purposes. Further valuable applications such as health-promoting properties are still under investigation. The seeds of the white berries of Mantonico and Pecorello cv. were extracted in a Soxhlet apparatus, using n-hexane and chloroform as solvents. Extracts were characterized by NMR and GC-MS analyses. They were assayed in vitro as wound healing and anti-inflammatory agents in HaCaT and RAW 264.7 cell lines, respectively. n-hexane Mantonico extract resulted in the most interesting wound healing sample, while n-hexane Pecorello, containing a good number of carotenoids, resulted in a good anti-inflammatory candidate. These preliminary findings underlined the benefit of grape seed extracts valorization due to their health-promoting properties.

SUBMITTER: Carullo G 

PROVIDER: S-EPMC7281466 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature

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Mantonico and Pecorello Grape Seed Extracts: Chemical Characterization and Evaluation of <i>In Vitro</i> Wound-Healing and Anti-Inflammatory Activities.

Carullo Gabriele G   Sciubba Fabio F   Governa Paolo P   Mazzotta Sarah S   Frattaruolo Luca L   Grillo Giorgio G   Cappello Anna Rita AR   Cravotto Giancarlo G   Di Cocco Maria Enrica ME   Aiello Francesca F  

Pharmaceuticals (Basel, Switzerland) 20200514 5


The winemaking process produces a huge number of pomaces that generally are used for energy purposes. Further valuable applications such as health-promoting properties are still under investigation. The seeds of the white berries of Mantonico and Pecorello <i>cv.</i> were extracted in a Soxhlet apparatus, using <i>n</i>-hexane and chloroform as solvents. Extracts were characterized by NMR and GC-MS analyses. They were assayed <i>in vitro</i> as wound healing and anti-inflammatory agents in HaCaT  ...[more]

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