Contribution of alcohol- and cigarette-related cues to concurrent reinforcer choice in humans.
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ABSTRACT:
SUBMITTER: Strickland JC
PROVIDER: S-EPMC7283006 | biostudies-literature |
REPOSITORIES: biostudies-literature
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Project description:BackgroundDrug-related cues play a critical role in the development and persistence of substance use disorder. Few human laboratory studies have evaluated how these cues contribute to decisions between concurrently presented reinforcers, and none have examined the specific role of cannabis cues. This study evaluated the contribution of cannabis-related cues to concurrent monetary reinforcer choice in humans.MethodsParticipants with a cannabis use history (i.e., use in the past two weeks and 50 or more lifetime uses; n = 71) and controls without this history (i.e., 5 or less lifetime uses; n = 79) were recruited using Amazon Mechanical Turk. A cued concurrent choice task was used in which cannabis trials presented two cues (one cannabis and one neutral) side-by-side followed by concurrent monetary offers below each image. The primary dependent measure was choice for cannabis-cued monetary reinforcers on equal value trials. Secondary analyses evaluated individual difference variables related to choice bias.ResultsParticipants in the cannabis group showed a significant bias for cannabis-cued choices (mean 76.0%) whereas participants in the control group showed a significant bias against cannabis-cued choices (mean 30.3%). Reaction times on cannabis trials were faster than neutral filler trials and did not differ by group. Cannabis-cued choice was significantly associated with more frequent cannabis use (r = .44), higher cannabis demand intensity (r = .28), and lower cannabis elasticity (r = -.30).ConclusionsThese findings suggest that cannabis-related cues can influence reinforcer choice and potentially promote disadvantageous decision-making related to non-drug reinforcers.
| S-EPMC6615729 | biostudies-literature
Project description:RATIONALE:Theoretical accounts highlight the importance of drug-related cues for the development and persistence of drug-taking behavior. Few studies have evaluated the ability of spatially contiguous drug cues to bias decisions between two concurrently presented non-drug reinforcers. OBJECTIVE:Evaluate the contribution of spatially contiguous cocaine cues to choice between two concurrently presented monetary reinforcers METHODS: Participants with cocaine use disorder completed a cued concurrent choice task. Two cues (one cocaine and one control image) were presented side-by-side followed by concurrent monetary offers below each image. Concurrent choice was measured for cocaine-side advantageous, equal, and disadvantageous concurrent monetary offers. The primary dependent measure was bias for selecting cocaine-cued monetary reinforcers. Three experiments tested selectivity of cocaine-cued bias in individuals with a cocaine use history (Experiment 1), replication when including additional control trials (Experiment 2), and a potential attentional mechanism evaluated using eye-tracking technology (Experiment 3). RESULTS:Significant and robust cocaine-cued bias at equal monetary value was observed in three experiments (mean percent choice?=?65-77%) and higher Drug Abuse Screening Test (DAST) scores were associated with greater cocaine-choice bias. These experiments demonstrated that cocaine-cued bias was (1) selective to individuals with a cocaine use history, (2) specific to trials involving a cocaine cue, and (3) partially associated with attentional bias. CONCLUSIONS:These experiments provide evidence that drug-related cues can influence choice and potentially promote maladaptive decision making during concurrent choice events. Future research evaluating prospective associations of drug-cued bias with drug-associated behaviors will help reveal the clinical relevance for substance use disorder.
| S-EPMC6162111 | biostudies-literature
Project description:IntroductionThe reasons that some smokers find it harder to quit than others are unclear. Understanding how individual differences predict smoking cessation outcomes may allow the development of more successful personalized treatments for nicotine dependence. Theoretical models suggest that drug users might be characterized by increased sensitivity to drug cues and by reduced sensitivity to nondrug-related natural rewards. We hypothesized that baseline differences in brain sensitivity to natural rewards and cigarette-related cues would predict the outcome of a smoking cessation attempt.MethodsUsing functional magnetic resonance imaging, we recorded prequit brain responses to neutral, emotional (pleasant and unpleasant), and cigarette-related cues from 55 smokers interested in quitting. We then assessed smoking abstinence, mood, and nicotine withdrawal symptoms during the course of a smoking cessation attempt.ResultsUsing cluster analysis, we identified 2 groups of smokers who differed in their baseline responses to pleasant cues and cigarette-related cues in the posterior visual association areas, the dorsal striatum, and the medial and dorsolateral prefrontal cortex. Smokers who showed lower prequit levels of brain reactivity to pleasant stimuli than to cigarette-related cues were less likely to be abstinent 6 months after their quit attempt, and they had higher levels of negative affect during the course of the quit attempt.ConclusionsSmokers with blunted brain responses to pleasant stimuli, relative to cigarette-related stimuli, had more difficulty quitting smoking. For these individuals, the lack of alternative forms of reinforcement when nicotine deprived might be an important factor underlying relapse. Normalizing these pathological neuroadaptations may help them achieve abstinence.
| S-EPMC4015090 | biostudies-literature
Project description:Chronic excessive alcohol intoxications evoke cumulative damage to tissues and organs. We examined prefrontal cortex (Brodmann's area (BA) 9) from 20 human alcoholics and 20 age, gender, and postmortem delay matched control subjects. H & E staining and light microscopy of prefrontal cortex tissue revealed a reduction in the levels of cytoskeleton surrounding the nuclei of cortical and subcortical neurons, and a disruption of subcortical neuron patterning in alcoholic subjects. BA 9 tissue homogenisation and one dimensional polyacrylamide gel electrophoresis (PAGE) proteomics of cytosolic proteins identified dramatic reductions in the protein levels of spectrin β II, and α- and β-tubulins in alcoholics, and these were validated and quantitated by Western blotting. We detected a significant increase in α-tubulin acetylation in alcoholics, a non-significant increase in isoaspartate protein damage, but a significant increase in protein isoaspartyl methyltransferase protein levels, the enzyme that triggers isoaspartate damage repair in vivo. There was also a significant reduction in proteasome activity in alcoholics. One dimensional PAGE of membrane-enriched fractions detected a reduction in β-spectrin protein levels, and a significant increase in transmembranous α3 (catalytic) subunit of the Na+,K+-ATPase in alcoholic subjects. However, control subjects retained stable oligomeric forms of α-subunit that were diminished in alcoholics. In alcoholics, significant loss of cytosolic α- and β-tubulins were also seen in caudate nucleus, hippocampus and cerebellum, but to different levels, indicative of brain regional susceptibility to alcohol-related damage. Collectively, these protein changes provide a molecular basis for some of the neuronal and behavioural abnormalities attributed to alcoholics.
| S-EPMC3974765 | biostudies-literature
Project description:Introduction and aimsImpulsivity may be a risk factor that increases vulnerability to nicotine dependence. However, nicotine exposure itself may directly increase impulsivity. This is a secondary analysis of the first study in a controlled laboratory setting, which assessed the effects of nicotine administration (acute and repeated) and exposure to smoking cues on behavioural impulsivity in humans (ClinicalTrials.gov Identifier: NCT01395797).Design and methodsTwenty-seven smokers completed three tasks to assess behavioural impulsivity (the Immediate Memory Task and the Delayed Memory Task assessing response initiation, and the GoStop Task assessing response inhibition) following: (i) 4 days of cigarette smoking (nicotinised or denicotinised cigarette); (ii) acute cigarette smoking (nicotinised); and (iii) exposure to smoking-related cues.ResultsFour days of nicotinised cigarette smoking (vs. denicotinised) did not significantly increase Immediate Memory Task, Delayed Memory Task and GoStop scores. However, acute cigarette smoking increased GoStop impulsivity, but only following 4 days of smoking nicotinised cigarettes (P < 0.05). Exposure to smoking-related cues had no statistically significant effect on impulsivity.Discussion and conclusionsOur results suggest that repeated nicotine exposure may sensitise subsequent acute nicotine effects on behavioural impulsivity in heavy smokers.
| S-EPMC8088442 | biostudies-literature
Project description:Cigarette craving is a cardinal feature of smoking, which is the leading preventable cause of death. Despite its clinical relevance, there remains a pressing need to develop new approaches for controlling craving. Although olfactory cues (OCs) are especially well suited to reduce affectively charged cravings, there has been surprisingly little research on the topic. We investigated the strategic use of OCs to reduce cigarette craving. Abstinent smokers (N = 232) initially sampled and rated a series of OCs. Participants then were exposed to in vivo smoking cues, which produced robust cigarette cravings. During peak craving, they were randomly assigned to sniff one of three types of OCs (all of which they had previously sampled) while their craving, and a set of responses thought to be associated with craving, were assessed. OCs that a participant had rated as pleasant reduced craving more than did exposure to odor blank (i.e., neutral) or tobacco-related OCs. This effect persisted over the course of 5 min. In addition, smokers with the most specific autobiographical memory systems were most responsive to the craving-reducing effects of pleasant OCs. About 90% of participants reported they could imagine using a pleasant OC to curb their craving in the natural environment. The present data suggest that OCs show promise for controlling cravings and highlight the need to conduct further research to test whether OCs may prove useful alone or in combination with existing approaches as a smoking cessation intervention. (PsycINFO Database Record (c) 2019 APA, all rights reserved).
| S-EPMC6529945 | biostudies-literature
Project description:While it is well documented that substance users exhibit attentional bias toward addiction-related stimuli, the exact mechanism remains unclear.To differentiate between distinct aspects of attentional allocation in the smoking-cue attentional bias observed in smokers.Active smokers (AS) and non-smoking controls completed spatial cueing tasks with pairs of smoking and neutral pictorial cues to measure attentional capture, and an attentional blink task with either a smoking or neutral image appearing behind the first target (T1) to measure aspects of attention separate from capture. In addition, we tested groups of sports enthusiasts, and non-enthusiasts in corresponding tasks replacing smoking images with sports-related images to address the possibility that effects found in the smoking study were due simply to greater stimulus familiarity.Smoking cues reflexively capture smokers' attention, as AS showed a greater bias toward smoking cues in short stimulus-onset asynchrony (SOA; the time between the onset of two stimuli) trials, but not in trials with a longer SOA. These effects represent a facilitation of responding to smoking- versus neutral-cued targets, and were absent in the sports control task. The attentional blink effects were similar in the smoking- and sports-cue experiments: the special T1 resulted in better detection of the second target for the smokers and sports enthusiasts.Stimulus familiarity may contribute to some aspects of attentional bias in regular nicotine users, but selective quick capture of attention by smoking cues may be nicotine-habit specific.
| S-EPMC2967198 | biostudies-literature
Project description:Our aim in the present study was to investigate the psychological mechanisms that underlie the disinhibiting effects of alcohol cues in social drinkers by contrasting motor and oculomotor inhibition after exposure to alcohol-related, emotional, and neutral pictures. We conducted 2 studies in which social drinkers completed modified stop-signal (laboratory) and antisaccade (online) tasks in which positive, negative, alcohol-related, and neutral pictures were embedded. We measured cue-specific disinhibition in each task, and investigated whether sex and drinking status moderated the effects of pictures on disinhibition. Across both studies, comparable increases in disinhibition were observed in response to both alcohol and negatively valenced pictures, relative to both positive and neutral pictures. These differences in disinhibition could not be explained by differences between picture sets in arousal or valence ratings. There was no clear evidence of moderation by sex or drinking status. Secondary analyses demonstrated that alcohol-specific disinhibition was not reliably associated with individual differences in alcohol consumption or craving. These results suggest that the disinhibiting properties of alcohol-related cues cannot be attributed solely to their valence or arousing properties, and that alcohol cues may have unique disinhibiting properties.
| S-EPMC4386809 | biostudies-other
Project description:Many arthropod pests of humans and other animals select their preferred hosts by recognising volatile odour compounds contained in the hosts' 'volatilome'. Although there is prolific literature on chemical emissions from humans, published data on volatiles and vector attraction in other species are more sporadic. Despite several decades since the identification of a small number of critical volatiles underpinning specific host-vector relationships, synthetic chemicals or mixtures still largely fail to reproduce the attractiveness of natural hosts to their disease vectors. This review documents allelochemicals from non-human terrestrial animals and considers where challenges in collection and analysis have left shortfalls in animal volatilome research. A total of 1287 volatile organic compounds were identified from 141 species. Despite comparable diversity of entities in each compound class, no specific chemical is ubiquitous in all species reviewed, and over half are reported as unique to a single species. This review provides a rationale for future enquiries by highlighting research gaps, such as disregard for the contribution of breath volatiles to the whole animal volatilome and evaluating the role of allomones as vector deterrents. New opportunities to improve vector surveillance and disrupt disease transmission may be unveiled by understanding the host-associated stimuli that drive vector-host interactions.
| S-EPMC7692281 | biostudies-literature
Project description:Unemployment, homelessness, and substance use are interrelated. The present study took place as part of a clinical trial aimed to promote employment and abstinence from alcohol in unemployed, homeless adults with alcohol use disorders. Participants earned abstinence-contingent financial incentives for completing employment-seeking activities and hourly stipends for working with an employment specialist. In the initial condition, participants were paid all earnings on Bi-Monthly intervals. Despite the availability of incentives for completing employment-seeking activities, participants completed activities at low rates. A multiple-baseline across participants was used to evaluate the effect of providing pay every day for completing employment-seeking activities. Daily pay increased rates of completing activities for all three participants. Results suggest that reinforcer immediacy can be an important parameter in the control of employment-seeking activities.
| S-EPMC8318350 | biostudies-literature