Needle-type organic electrochemical transistor for spatially resolved detection of dopamine.

ABSTRACT: In this work, the advantages of carbon nanoelectrodes (CNEs) and orgonic electrochemical transistors (OECTs) were merged to realise nanometre-sized, spearhead OECTs based on single- and double-barrel CNEs functionalised with a conducting polymer film. The needle-type OECT shows a high aspect ratio that allows its precise positioning by means of a macroscopic handle and its size is compatible with single-cell analysis. The device was characterised with respect to its electrolyte-gated behaviour and was employed as electrochemical sensor for the proof-of-concept detection of dopamine (DA) over a wide concentration range (10^-12-10^-6 M). Upon application of fixed drain and gate voltages (V_d?=?-?0.3 V, V_g?=?-?0.9 V, respectively), the nano-sized needle-type OECT sensor exhibited a linear response in the low pM range and from 0.002 to 7 ?M DA, with a detection limit of 1?×?10^-12 M. Graphical abstract.

SUBMITTER: Mariani F 

PROVIDER: S-EPMC7283208 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature