Ontology highlight
ABSTRACT:
SUBMITTER: Wang X
PROVIDER: S-EPMC7283433 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Wang Xueqin X Song Yaying Y Chen Jie J Zhang Shuibing S Le Yuan Y Xie Zhongcong Z Ouyang Wen W Tong Jianbin J
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 20200401 2
Post-sepsis cognitive impairment is one of the major sequelae in sepsis survivors. Its prevention remains clinically challenging. Here we tested the effects and underlying mechanisms of exogenous β-hydroxybutyrate (BHB) on post-sepsis cognitive impairment. We found that subcutaneous administration of BHB increased survival and body weight recovery of sepsis mice and improved learning and memory of sepsis surviving mice in a cecal ligation and perforation-induced sepsis model. Additionally, the i ...[more]