Ontology highlight
ABSTRACT:
SUBMITTER: Dang HX
PROVIDER: S-EPMC7286679 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Science advances 20200610 24
Tumor heterogeneity and evolution drive treatment resistance in metastatic colorectal cancer (mCRC). Patient-derived xenografts (PDXs) can model mCRC biology; however, their ability to accurately mimic human tumor heterogeneity is unclear. Current genomic studies in mCRC have limited scope and lack matched PDXs. Therefore, the landscape of tumor heterogeneity and its impact on the evolution of metastasis and PDXs remain undefined. We performed whole-genome, deep exome, and targeted validation se ...[more]