Ontology highlight
ABSTRACT:
SUBMITTER: Greaves M
PROVIDER: S-EPMC3367003 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Cancers evolve by a reiterative process of clonal expansion, genetic diversification and clonal selection within the adaptive landscapes of tissue ecosystems. The dynamics are complex, with highly variable patterns of genetic diversity and resulting clonal architecture. Therapeutic intervention may destroy cancer clones and erode their habitats, but it can also inadvertently provide a potent selective pressure for the expansion of resistant variants. The inherently Darwinian character of cancer ...[more]