Circulating Exosomal Gastric Cancer-Associated Long Noncoding RNA1 as a Biomarker for Early Detection and Monitoring Progression of Gastric Cancer: A Multiphase Study.

ABSTRACT:

Importance

The gastric cancer (GC)-associated long noncoding RNA1 (lncRNA-GC1) plays an important role in gastric carcinogenesis. However, exosomal lncRNA-GC1 and its potential role in GC are poorly understood.

Objective

To evaluate the diagnostic value of circulating exosomal lncRNA-GC1 for early detection and monitoring progression of GC.

Design, setting, and participants

We performed a multiphase investigation of circulating exosomal lncRNA-GC1 for early detection of GC involving consecutive patients with GC (n = 522), patients with gastric precancerous lesions (n = 85), and healthy donor individuals (HDs; n = 219) from December 2016 to February 2019 at Chinese People's Liberation Army General Hospital, China. LncRNA-GC1 was measured by reverse transcription-polyme

SUBMITTER: Guo X 

PROVIDER: S-EPMC7287948 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature