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Synthesis and Cytotoxic Activity of Chiral Sulfonamides Based on the 2-Azabicycloalkane Skeleton.

ABSTRACT: A series of chiral sulfonamides containing the 2-azabicycloalkane scaffold were prepared from aza-Diels-Alder cycloadducts through their conversion to amines based on 2-azanorbornane or the bridged azepane skeleton, followed by the reaction with sulfonyl chlorides. The cytotoxic activity of the obtained bicyclic derivatives was evaluated using human hepatocellular carcinoma (HCC), medulloblastoma (MB), and glioblastoma (GBM) cell lines. Chosen compounds were shown to notably reduce cell viability as compared to nonmalignant cells.

SUBMITTER: Samadaei M

PROVIDER: S-EPMC7288168 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature

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Synthesis and Cytotoxic Activity of Chiral Sulfonamides Based on the 2-Azabicycloalkane Skeleton.

Samadaei Mahzeiar M Pinter Matthias M Senfter Daniel D Madlener Sibylle S Rohr-Udilova Nataliya N Iwan Dominika D Kamińska Karolina K Wojaczyńska Elżbieta E Wojaczyński Jacek J Kochel Andrzej A

Molecules (Basel, Switzerland) 20200518 10

A series of chiral sulfonamides containing the 2-azabicycloalkane scaffold were prepared from aza-Diels-Alder cycloadducts through their conversion to amines based on 2-azanorbornane or the bridged azepane skeleton, followed by the reaction with sulfonyl chlorides. The cytotoxic activity of the obtained bicyclic derivatives was evaluated using human hepatocellular carcinoma (HCC), medulloblastoma (MB), and glioblastoma (GBM) cell lines. Chosen compounds were shown to notably reduce cell v ...[more]

PMID: 32443610

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