Ontology highlight
ABSTRACT:
SUBMITTER: Iwan D
PROVIDER: S-EPMC7664408 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Iwan Dominika D Kamińska Karolina K Wojaczyńska Elżbieta E Psurski Mateusz M Wietrzyk Joanna J Daszkiewicz Marek M
Materials (Basel, Switzerland) 20201106 21
In a search for new, selective antitumor agents, we prepared a series of sulfonamides built on bicyclic scaffolds of 2-azabicyclo(2.2.1)heptane and 2-azabicyclo(3.2.1)octane. To this end, <i>aza</i>-Diels-Alder cycloadducts were converted into amines bearing 2-azanorbornane or a bridged azepane skeleton; their treatment with sulfonyl chlorides containing biaryl moieties led to the title compounds. The study of antiproliferative activity of the new agents showed that some of them inhibited the gr ...[more]