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Magnetic Nanoparticles Coated with (R)-9-Acetoxystearic Acid for Biomedical Applications.


ABSTRACT: The well-known ability to selectively drive nanomagnetic materials coated with anticancer drugs into tumor cells suggested the synthesis and the characterization of magnetic nanoparticles (MNPs) functionalized with (R)-9-acetoxystearic acid, the acetic ester of (R)-9-hydroxystearic acid (9-HSA), an antiproliferative agent active against different cancer cells. The acyl chloride of (R)-9-acetoxystearic acid, synthesized in two steps from 9-HSA, was reacted with (3-aminopropyl)triethoxysilane, chosen as a linker between MNPs and the stearyl moiety. In the last step, the novel amide was bound to magnetite NPs by reaction with silyl groups. A detailed structural, chemical, and magnetic characterization of the obtained material proved that it possesses properties in agreement with the requirements for drug delivery, opening the possibility to further insights focused on the 9-HSA biomedical applications.

SUBMITTER: Micheletti G 

PROVIDER: S-EPMC7288358 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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Magnetic Nanoparticles Coated with (<i>R</i>)-9-Acetoxystearic Acid for Biomedical Applications.

Micheletti Gabriele G   Boga Carla C   Telese Dario D   Cassani Maria Cristina MC   Boanini Elisa E   Nitti Patrizia P   Ballarin Barbara B   Ghirri Alberto A   Barucca Gianni G   Rinaldi Daniele D  

ACS omega 20200529 22


The well-known ability to selectively drive nanomagnetic materials coated with anticancer drugs into tumor cells suggested the synthesis and the characterization of magnetic nanoparticles (MNPs) functionalized with (<i>R</i>)-9-acetoxystearic acid, the acetic ester of (<i>R</i>)-9-hydroxystearic acid (9-HSA), an antiproliferative agent active against different cancer cells. The acyl chloride of (<i>R</i>)-9-acetoxystearic acid, synthesized in two steps from 9-HSA, was reacted with (3-aminopropyl  ...[more]

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