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Catalyst- and Additive-Free Method for the Synthesis of 2-Substituted Benzothiazoles from Aromatic Amines, Aliphatic Amines, and Elemental Sulfur.

ABSTRACT: Under catalyst- and additive-free conditions, a novel, convenient, environmentally friendly method was developed for the synthesis of 2-substituted benzothiazoles via the three-component one pot reaction from aromatic amines, aliphatic amines, and elemental sulfur. The reaction achieves double C-S and one C-N bond formations via cleavage of two C-N bonds and multiple C-H bonds. Furthermore, the mechanism research shows that DMSO acts as an oxidant in the cyclization reaction.

SUBMITTER: Zhu X

PROVIDER: S-EPMC7288589 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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Catalyst- and Additive-Free Method for the Synthesis of 2-Substituted Benzothiazoles from Aromatic Amines, Aliphatic Amines, and Elemental Sulfur.

Zhu Xiaoming X Zhou Fengru F Yang Yuan Y Deng Guobo G Liang Yun Y

ACS omega 20200529 22

Under catalyst- and additive-free conditions, a novel, convenient, environmentally friendly method was developed for the synthesis of 2-substituted benzothiazoles via the three-component one pot reaction from aromatic amines, aliphatic amines, and elemental sulfur. The reaction achieves double C-S and one C-N bond formations via cleavage of two C-N bonds and multiple C-H bonds. Furthermore, the mechanism research shows that DMSO acts as an oxidant in the cyclization reaction. ...[more]

PMID: 32548500

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