Ontology highlight
ABSTRACT:
SUBMITTER: Richeson KV
PROVIDER: S-EPMC7289404 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Nature chemical biology 20200309 5
The anaphase-promoting complex/cyclosome (APC/C) is a ubiquitin ligase that initiates anaphase and mitotic exit. APC/C is activated by Cdc20 and inhibited by the mitotic checkpoint complex (MCC), which delays mitotic exit when the spindle assembly checkpoint (SAC) is activated. We previously identified apcin as a small molecule ligand of Cdc20 that inhibits APC/C<sup>Cdc20</sup> and prolongs mitosis. Here we find that apcin paradoxically shortens mitosis when SAC activity is high. These opposing ...[more]