Ontology highlight
ABSTRACT:
SUBMITTER: Eckert AF
PROVIDER: S-EPMC7289602 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Eckert Antonia Franziska AF Gao Peng P Wesslowski Janine J Wang Xianxian X Rath Jasmijn J Nienhaus Karin K Davidson Gary G Nienhaus Gerd Ulrich GU
eLife 20200522
Development and homeostasis of multicellular organisms is largely controlled by complex cell-cell signaling networks that rely on specific binding of secreted ligands to cell surface receptors. The Wnt signaling network, as an example, involves multiple ligands and receptors to elicit specific cellular responses. To understand the mechanisms of such a network, ligand-receptor interactions should be characterized quantitatively, ideally in live cells or tissues. Such measurements are possible usi ...[more]