The Role of Human ?? T Cells in Anti-Tumor Immunity and Their Potential for Cancer Immunotherapy.

ABSTRACT: ?? T cells are a distinct subset of T cells whose T cell receptors consist of ? chains and ? chains, different from conventional ?? T cells. ?? T cells are considered as a member of the innate immunity because of their non-MHC restricted antigen recognition, rapid response to invading pathogens and sense early changes of malignant cells. Upon activation, they can further promote the activation of adaptive immune cells, such as T cells and B cells, by secreting various cytokines. Thus, ?? T cells are regarded as a bridge between innate immunity and acquired immunity. ?? T cells are involved in a variety of immune response processes, including immune defense and immune surveillance against infection and tumorigenesis. ?? T cells recognize multiple tumor-associated antigens or molecules in T cell receptors (TCRs)-dependent and natural killer cell receptors (NKRs)-dependent ways. ?? T cells not only display a direct killing capacity on a variety of tumors, but also exert anti-tumor immune responses indirectly by facilitating the function of other immune cells, such as dendritic cells (DCs), B cells and CD8+ T cells. In this review, we summarize the major subpopulations, the tumor recognition mechanisms, and the anti-tumor effects of human ?? T cells, particularly the potential of ?? T cells for cancer immunotherapy.

SUBMITTER: Liu Y 

PROVIDER: S-EPMC7290839 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature