Ontology highlight
ABSTRACT:
SUBMITTER: Brownsword MJ
PROVIDER: S-EPMC7291021 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Brownsword Matthew J MJ Doyle Nicole N Brocard Michèle M Locker Nicolas N Maier Helena J HJ
Viruses 20200514 5
Viruses must hijack cellular translation machinery to express viral genes. In many cases, this is impeded by cellular stress responses. These stress responses result in the global inhibition of translation and the storage of stalled mRNAs, into RNA-protein aggregates called stress granules. This results in the translational silencing of the majority of mRNAs excluding those beneficial for the cell to resolve the specific stress. For example, the expression of antiviral factors is maintained duri ...[more]