Ontology highlight
ABSTRACT:
SUBMITTER: Krenzien F
PROVIDER: S-EPMC7291032 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Krenzien Felix F Katou Shadi S Papa Alba A Sinn Bruno B Benzing Christian C Feldbrügge Linda L Kamali Can C Brunnbauer Philipp P Splith Katrin K Lorenz Ralf Roland RR Ritschl Paul P Wiering Leke L Öllinger Robert R Schöning Wenzel W Pratschke Johann J Schmelzle Moritz M
Journal of clinical medicine 20200520 5
Donor organ quality is crucial for transplant survival and long-term survival of patients after liver transplantation. Besides bacterial and viral infections, endogenous damage-associated molecular patterns (DAMPs) can stimulate immune responses. Cell-free DNA (cfDNA) is one such DAMP that exhibits highly proinflammatory effects via DNA sensors. Herein, we measured cfDNA after liver transplantation and found elevated levels when organs from resuscitated donors were transplanted. High levels of c ...[more]