Ontology highlight
ABSTRACT:
SUBMITTER: Orthmann-Murphy J
PROVIDER: S-EPMC7292648 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Orthmann-Murphy Jennifer J Call Cody L CL Molina-Castro Gian C GC Hsieh Yu Chen YC Rasband Matthew N MN Calabresi Peter A PA Bergles Dwight E DE
eLife 20200527
Destruction of oligodendrocytes and myelin sheaths in cortical gray matter profoundly alters neural activity and is associated with cognitive disability in multiple sclerosis (MS). Myelin can be restored by regenerating oligodendrocytes from resident progenitors; however, it is not known whether regeneration restores the complex myelination patterns in cortical circuits. Here, we performed time lapse in vivo two photon imaging in somatosensory cortex of adult mice to define the kinetics and spec ...[more]