Apolipoprotein L-1 renal risk variants form active channels at the plasma membrane driving cytotoxicity.
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ABSTRACT:
SUBMITTER: Giovinazzo JA
PROVIDER: S-EPMC7292663 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Publications
Apolipoprotein L-1 renal risk variants form active channels at the plasma membrane driving cytotoxicity.
Giovinazzo Joseph A JA Thomson Russell P RP Khalizova Nailya N Zager Patrick J PJ Malani Nirav N Rodriguez-Boulan Enrique E Raper Jayne J Schreiner Ryan R
eLife 20200519
Recently evolved alleles of Apolipoprotein L-1 (<i>APOL1</i>) provide increased protection against African trypanosome parasites while also significantly increasing the risk of developing kidney disease in humans. APOL1 protects against trypanosome infections by forming ion channels within the parasite, causing lysis. While the correlation to kidney disease is robust, there is little consensus concerning the underlying disease mechanism. We show in human cells that the APOL1 renal risk variants ...[more]
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