Ontology highlight
ABSTRACT:
SUBMITTER: Li Y
PROVIDER: S-EPMC7294131 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Li Yandong Y Feng Jie J Li Yan Y Hu Shengshou S Nie Yu Y
Journal of cellular and molecular medicine 20200428 11
The neonatal heart completely regenerates after apical resection (AR), providing a desirable research model to study the mechanism of cardiac regeneration and cardiomyocyte proliferation. However, AR-induced neonatal heart regenerative phenomenon is controversial due to the variation of operative details in different laboratories. Here, we provide an optimized AR operation procedure with stable regeneration and high survival rate by achieving heart exposure, normalizing myocardium cut-offs, and ...[more]