Ontology highlight
ABSTRACT:
SUBMITTER: Zhou M
PROVIDER: S-EPMC7294933 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Zhou Mimi M Chen Jinqiu J Zhang Hui H Liu Hailing H Yao Huan H Wang Xiaman X Zhang Wanggang W Zhao Yingren Y Yang Nan N
International journal of biological sciences 20200515 12
Krüppel-like factor 10 (KLF10) has been identified as an important regulator in carcinogenesis and cancer progression. However, the role of KLF10 in multiply myeloma (MM) development and progression remains unknown. In present study, we found that KLF10 mRNA and protein were down-regulated in MM tissues and cell lines. Notably, KLF10 inhibited cell proliferation, cell cycle progression and promoted apoptosis <i>in vitro</i> and <i>in vivo</i>. Furthermore, we confirmed that KLF10 inhibited β-cat ...[more]