Ontology highlight
ABSTRACT:
SUBMITTER: Ganesh K
PROVIDER: S-EPMC7295073 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Ganesh Karuna K Stadler Zsofia K ZK Cercek Andrea A Mendelsohn Robin B RB Shia Jinru J Segal Neil H NH Diaz Luis A LA
Nature reviews. Gastroenterology & hepatology 20190601 6
Following initial successes in melanoma treatment, immunotherapy has rapidly become established as a major treatment modality for multiple types of solid cancers, including a subset of colorectal cancers (CRCs). Two programmed cell death 1 (PD1)-blocking antibodies, pembrolizumab and nivolumab, have shown efficacy in patients with metastatic CRC that is mismatch-repair-deficient and microsatellite instability-high (dMMR-MSI-H), and have been granted accelerated FDA approval. In contrast to most ...[more]