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Association Between Irritable Bowel Syndrome and Sleep Disturbance in Adolescents.

ABSTRACT: Introduction:Sleep disorder in adolescents is a problem that is rarely considered by both parents and healthcare professionals. Ignorance of sleep disorders is likely caused by the very rare occurrence of associated sporadic or emergency cases. Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder characterized by abdominal pain and changes in the defecation pattern. Previous research has demonstrated IBS as one of the many causes of sleep disorders. Difficulty sleeping, frequent awakening, and difficulty returning to sleep after awakening are the symptoms often experienced by adolescents with IBS. The high incidence of IBS in adolescents and the large proportion of sleep disorders in IBS affect the quality of life and disrupt physical development, behaviour, and learning achievement. The relationship between IBS and sleep disorders in adolescents needs to be studied. This study aims to determine the relationship between sleep disorders and IBS in high school adolescents in Palembang. Methods:This is a cross-sectional study conducted on 294 high school adolescents in Palembang in June 2018. Random sampling method was used and the presence of IBS and sleep disturbances were assessed using a questionnaire. Results:Among all subjects, we found 113 subjects (38.4%) with IBS. Of these 113 subjects with IBS, only 60 subjects (53.1%) experienced sleep disorders. Conclusion:No correlation found between sleep disorders and IBS in adolescents.

SUBMITTER: Indah Kusumawati Noor L

PROVIDER: S-EPMC7295206 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Association Between Irritable Bowel Syndrome and Sleep Disturbance in Adolescents.

Indah Kusumawati Noor Laili L Bakri Achirul A Soejadhi Rismarini R Kesuma Yudianita Y

Adolescent health, medicine and therapeutics 20200611

<h4>Introduction</h4>Sleep disorder in adolescents is a problem that is rarely considered by both parents and healthcare professionals. Ignorance of sleep disorders is likely caused by the very rare occurrence of associated sporadic or emergency cases. Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder characterized by abdominal pain and changes in the defecation pattern. Previous research has demonstrated IBS as one of the many causes of sleep disorders. Difficulty sleepin ...[more]

PMID: 32607040

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Project description:BACKGROUND:Irritable bowel syndrome (IBS) is one of the most common functional intestinal diseases, but its pathogenesis is still unknown. The present study aimed to screen the differentially expressed proteins in the mucosa of colon between IBS with diarrhea (IBS-D) patients and the healthy controls. METHODS:Forty-two IBS-D patients meeting the Rome III diagnostic criteria and 40 control subjects from July 2007 to June 2009 in Chinese PLA General Hospital were enrolled in the present study. We examined the protein expression profiles in mucosa of colon corresponding to IBS-D patients (n?=?5) and controls (n?=?5) using 2-dimensional gel electrophoresis (2-DE) and mass spectrometry (MS). Secondly, Western blot and immunohistochemical analysis were carried out to validate the screened proteins in 27 IBS-D patients and 27 controls. Thirdly, high-performance liquid chromatography (HPLC) was further carried out to determine ATP concentration in the mucosa of colon between 10 IBS-D patients and 8 controls. Comparisons between 2 groups were performed by Student's t-test or Mann-Whitney U-test. RESULTS:Twelve differentially expressed proteins were screened out. The ?-enolase (ENOA) in the sigmoid colon (0.917?±?0.007 vs. 1.310?±?0.100, t?=?2.643, P?=?0.017) and caecum (0.765?±?0.060 vs. 1.212?±?0.122, t?=?2.225, P?=?0.023), Isobutyryl-CoA dehydrogenase (ACAD8) in the sigmoid colon (1.127?±?0.201 vs. 1.497?±?0.392, t?=?7.093, P?=?0.008) of the IBS-D group were significantly lower while acetyl-CoA acetyltransferase (CT) in the caecum (2.453?±?0.422 vs. 0.931?±?0.652, t?=?8.363, P?=?0.015) and ATP synthase subunit d (ATP5H) in the sigmoid (0.843?±?0.042 vs. 0.631?±?0.042, t?=?8.613,P?=?0.007) of the IBS-D group was significantly higher, compared with the controls. The ATP concentration in the mucosa of the sigmoid colon in IBS-D group was significantly lower than that of control group (0.470 [0.180, 1.360] vs. 5.350 [2.230, 7.900], U?=?55, P?<?0.001). CONCLUSIONS:Many proteins related to energy metabolism presented differential expression patterns in the mucosa of colon of the IBS-D patients. The abnormalities in energy metabolism may be involved in the pathogenesis of IBS which deserves more studies to elucidate.

Dataset Information

Association Between Irritable Bowel Syndrome and Sleep Disturbance in Adolescents.

Publications

Association Between Irritable Bowel Syndrome and Sleep Disturbance in Adolescents.

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